The debut of the sixth-generation Seigaku cast along with the first-generation Fudomine cast.

Seigaku vs. Fudomine is the first performance of season two. The musical combined Echizen Ryoma's Seigaku introduction arc up to his match with Tezuka Kunimitsu. Seigaku vs. Fudomine's first season equivalent is Musical Tennis no Ouji-sama and Remarkable 1st Match Fudomine.

It ran from January 5 to February 11, 2011.